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In this context, CAR-T therapy presents an unprecedented opportunity to address the underlying immunopathology in the field of SLE by engineering T cells to specifically recognize and eliminate autoreactive B cells and plasma cells
Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025
Additionally, vitamin C levels in the dermis of patients with AD are significantly lower compared to those of healthy individuals (38, 91)
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