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Acute pancreatitis promotes the expression of NO and inducible nitric oxide synthase (iNOS), which activates the NF-B signaling pathway, and mediates the increase induced by spinal cord cyclooxygenase-2 (COX-2) via IL-1, and stimulates pain in the body [101]

M., Mustapha, F., Jai, J

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Similar to what we found in the large cohort of the whole blood analyses (Fig