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doi: 10.1111/adb.12425 [DOI] [PMC free article] [PubMed] [Google Scholar] 36.McKee SA, Harrison EL, OMalley SS, et al

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The two main signaling cascades started by IGF1 LR3 receptor binding are the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the mitogen-started protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway