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Biotin mainly supports hair, skin, and nail health, while glutathione supports antioxidant protection and cellular repair

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(10 g or 10 ng/kg/day), topical (1.0 g in cream), or per-oral (0.16 g/mL in drinking water) over 90 days and described directional improvements across biomechanical, functional, macroscopic, and histological endpoints, though specific effect sizes and p-values are not reported in the abstract

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For an excellent review of diagnostic issues in fatigue-associated conditions and brain effects, see Baraniuk (2023), FM, and GWS