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Mechanism of Action MT2 exerts its activity by acting as an agonist at melanocortin receptors distributed throughout the body and brain

How dosing works Your dose will increase every 2 weeks until you reach the maximum dose

Commonly prescribed GLP-1 receptor agonists include semaglutide (sold under brand names like Wegovy and Ozempic) and tirzepatide (marketed as Mounjaro)

Healthcare professionals should approach disclosures of combined peptide use with a non-judgemental but clinically thorough assessment, and provide harm-minimisation advice where appropriate

Genetic differences, beta-cell function, and baseline insulin resistance can all influence treatment response

A calculated estimate of insulin resistance using the homeostatic model assessment for insulin resistance (HOMA-IR) demonstrated a significant reduction in the HOMA-IR score to almost undetectable levels with RETA treatment, an approximation suggesting a loss of insulin resistance (Supplementary Fig