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A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]

For people who are curious about GLP-1s but want to start slowly, Nooms Microdose GLP-1 program may be a helpful first step

Whether this reflects the reward pathway modulation seen in animal studies or simply reduced overall appetite (including appetite for alcohol) remains an active area of investigation

Greek yogurt, protein smoothies, and cold chicken or shrimp all work well

Unlike the large synthetic molecule semaglutide, orforglipron is a small molecule, though both act by mimicking GLP-1