Figure 1 Recent work of our group identified several serum proteins as potential targets for haptenation by amoxicillin (AX) ( In vitro , incubation of human serum albumin (HSA) with AX, results in the modification of several lysine residues of which, Lys190 and Lys195 appear to be the most reactive ( Previous studies with the antibiotic sulfamethoxazole have shown that oxidative stress can potentiate the formation of protein adducts in cells ( Materials and Methods Reagents Dithiothreitol (DTT), glutathione (GSH), 2-mercaptoethanol, -NADPH, 5,5-dithio-bis-(2-nitrobenzoic acid), ethanothiol, triethanolamine, 2-vinylpyridine, sulfosalicylic acid, bovine serum albumin (BSA), buthionine sulfoximine (BSO), tris(2-carboxyethyl)phosphine (TCEP), N-acetyl-L-cysteine, L-cysteine, cefaclor, and cephadroxil were products of Sigma
Wozniakowski, G
This is to further facilitate its application in the pharmaceutical and nutraceutical industries
Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway
Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y,
Fed Proc
