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Phase II data showed 24.2% body weight reduction at 48 weeks

Fiber: Constipation is common on GLP-1s, and low fiber is often the culprit

6-10 GLP-1 receptor agonists work to lower glycemia via several mechanisms

The published Phase 2 obesity trial measured weight change at 24 weeks and again at 48 weeks, reporting dose-dependent mean reductions of up to 17.5% and up to 24.2% respectively

The clinical significance in humans remains under investigation, but it's why thyroid monitoring is worth including in your baseline and annual testing

For a full breakdown of what to expect week by week, see our realistic results timeline