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Besides well-known oxidants or electrophiles, such as H 2 O 2 , 4-hydroxynonenal, and diethyl maleate (DEM), which also possess cytotoxicity, only few Nrf2 activators have been found to be useful in clinical trials (Sun et al

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Ward et al., 2019), including muscular pain, nocturnal muscle cramping, weakness, rare rhabdomyolysis, and amyotrophic lateral sclerosis (ALS)-like muscle wasting conditions (Bai et al., 2021)