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Owing to the high oxygen demand of tumor cells, the hypoxic state of the TME activates the HIF-1 pathway, promoting tumor cell proliferation and chemoresistance

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Dou X, Li S, Wang Z, Gu D, Shen C, Yao T

90 KybaC

Ferroptosis Overview of ferroptosis Ferroptosis is a recently identified kind of iron-dependent cellular death marked by iron accumulation and an accumulation of lipid peroxidation

For HIF transcription factors, this occurs by hydroxylation at conserved proline residues by prolyl hydroxylases under normoxia, allowing their recognition and ubiquitination by the VHL E3 ubiquitin ligase, which targets HIFs for proteasomal degradation