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The SURMOUNT trials demonstrated up to 22.5 percent body weight reduction with tirzepatide at the highest doses

Current evidence suggests that the adverse effects sometimes associated with taurine are due to the use of large amounts of stimulants in combination with alcohol and/or intense physical exercise

Most gastrointestinal symptoms are dose-dependent and typically resolve within the first few weeks of treatment

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Key finding: Retatrutide reduced activation in nucleus accumbens and lateral orbitofrontal cortex (p=0.014) and decreased self-reported hunger by 6.2 1.1 points vs 0.3 1.3 placebo

However, these side effects tend to be temporary and may go away as the body adjusts to the medication