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On the other hand, PGC-1/NRF1 regulates FUNDC1-mediated mitophagy through transcription, promoting mitochondrial biogenesis during the process of mitochondrial autophagy, accelerating mitochondrial turnover, and maintaining normal mitochondrial respiration and mitochondrial population stability

And, given that the brain affects weight loss, this means that all of the weird ways that receptors work in the brain still apply

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Because tesamorelin works via the GH axis rather than the incretin system, its metabolic effects are more targeted and narrower in scope

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However, it's crucial to note that these treatments are not universally recommended for everyone