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Incidences of other toxicities were comparable across the three treatment groups in DURATION-8 (exenatide plus dapagliflozin, exenatide alone, and dapagliflozin alone, respectively), including pancreatitis (1.3%, 0.4%, and 0%), volume depletion (1.3%, 0.4%, and 2.1%), gastrointestinal events (20.8%, 23.9%, and 16.3%), and genital infections (5.2%, 2.2%, and 7.7%) [36]

Compounded semaglutide is suitable for patients who need customized medication to fulfill their medical needs

Considering the variability introduced by hormonal fluctuations such as estrogen, only male mice were used to ensure experimental uniformity

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When weekly dose exposure is equivalent, outcomes are comparable

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