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reported that CircXRN2 can inhibit the degradation of LATS1, thereby activating the Hippo signaling pathway, inhibiting glycolysis and lactate production, subsequently suppressing H3K18la, and ultimately inhibiting the progression of bladder cancer mediated by histone lactylation [35]

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Serious adverse reactions are exceptionally rare

Nagana Gowda GA, Lusk JA, Pascua V

In summary, the relatively higher expression of GLP-1R on -cells allows GLP-1 to indirectly inhibit glucagon secretion by promoting somatostatin secretion