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Iron overload induces the separation of IRP1 from IRE-like sequence, activating NOX4 transcription, increasing lipid peroxidation accumulation, and leading to significant dysregulation of mitochondrial morphology and function of osteoblasts

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demonstrated that L-CN supplementation reduced the levels of serum CRP (a marker of systemic inflammation) and plasma fibrinogen (an inflammation-associated coagulation factor) in patients who underwent hemodialysis 34 , increased total antioxidant capacity, and decreased IL-6 and TNF-, which were effective in decreasing inflammatory status 35

Methods All chemicals were purchased from Carl Roth or Sigma-Aldrich, unless otherwise stated

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