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doi: 10.1016/j.cmet.2013.04.008 19 RetnakaranRKramerCKChoiHSwaminathanBZinmanB

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53 In longer studies of 612 months ( n = 2887), combining 5002000 mg/day metformin with various COCPs led to greater reductions in FAI, free testosterone, and inflammatory markers, and improvements in body composition, facial hirsutism, vascular function, and aortic elasticity than either treatment alone, although no additional benefits were seen for lipids, insulin sensitivity, SHBG, or testosterone beyond those provided by COCPs alone