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Known side effects (class effects similar to other GLP-1 medications) Gastrointestinal issues (very common): Nausea: 38-43% of participants vs 11% placebo Diarrhea: 33-35% vs 13% placebo Vomiting: 20-21% vs 0% placebo Constipation: 22-25% vs 9% placebo Decreased appetite: 18-19% vs 9% placebo These are expected with incretin-based therapies and typically improve over time as your body adjusts

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While simple fatty liver rarely causes problems, MASH can progress to cirrhosis and liver failure over years or decades

However, we have tried to make a more equitable comparison by choosing similar timepoints across all drugs (when available) and summarise them below

Some of the main benefits that come with the contraceptive pill include: Less pain