Second, in addition to Fenton reaction mediation, iron exerts a strong effect on cell death programs, such as by cleaving Fas and other death receptors or stimulating oxidation of the mitochondrial outer membrane protein Tom20, which triggers pyroptosis [122]
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Bull Natl Res Cent 44 , 18 (2020)
We next investigated whether mitochondria are the source of ROS generation in RPE cells upon GSH depletion, we used MitoSOX Red to detect mitochondrial ROS (Fig
For the methylcobalamin and glutathione monoanion model, the orbital contribution from the first structure is negligible, while the contribution from the second structure dominates in the HOMO (Fig