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Insulin signaling and neurotransmission Insulin can cross the blood-brain barrier from the periphery but it is also locally produced in the brain, where it binds to insulin receptors on neurons and glial cells [6]

doi:10.1097/MOU.0000000000000828

Lipid peroxidation of the mitochondrial membrane produces toxic molecules such as 4-hydroxynonenal and malondialdehyde, which in turn disturb mitochondrial membrane fluidity.108109 The impaired mitochondrial membrane leads to dysregulation in ionic balances and excessive intracellular calcium influx, which consequently causes neuronal death and impairs synaptic plasticity.110111112 NEUROPROTECTIVE AND ANTI-INFLAMMATORY THERAPY IN SCHIZOPHRENIA Randomized controlled trials have investigated the efficacy of adjuvant COX-2 inhibitor on antipsychotics treatment in schizophrenia

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Coenzyme Q10 Coenzyme Q10 (CoQ10) is involved in mitochondrial energy production and is best known for its beneficial effects on the cardiovascular system and metabolism

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