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U., Fontana, A., Schraermeyer, U., Thumann, G., & Weller, M

The depolarization and resulting activation of AMPA and NMDA receptors in the postsynaptic cell causes endocytosis of these receptors

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This inhibition reduces intracellular 1-methylnicotinamide (1-MNA) production (EC50 = 2.3 M) and preserves nicotinamide availability for the NAD+ salvage pathway

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