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In particular, glabellar frown lines become indented between the brows

Tirzepatide belongs to a novel class of medicines known as dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists

As of December 2025, there are no peer-reviewed trials directly examining whether a GLP-1 agonist helps or harms exercise performance in athletes

Table 1 Literature review of primary malignant spinal cord melanoma

The same study also illustrated that upregulation of GLP-1 via gene transfer was associated with enhanced learning and memory, providing evidence of the role GLP-1 has in hippocampal function [57]