dulaglutide -1.1 percent (1.5 mg)] compared to placebo (0.1 percent)
Julius, M., Lang, C
CVS likely has a complex neuronal and neurotransmitter underpinning, but has also been postulated to involve the gut microbiome, autonomic reactivity, gastric motility, mitochondrial disorders, and the HPA axis, which means it could be all of the above, and the greatest contributing factors may vary by patient [ 1,5]
This can be especially appealing for patients who are nervous about nausea, have a history of medication sensitivity, are close to their goal weight, want help with food noise rather than aggressive weight loss, or prefer a more conservative plan
This is a traditional bland-food diet that are low in fibre and easy to digest (bananas, rice, applesauce, toast) helpful during acute episodes Avoid known triggers such as spicy foods, caffeine, alcohol and fatty or fried foods Consume soluble fibre sources like oats and psyllium to add bulk to stools Eat smaller, more frequent meals rather than large portions Stay well-hydrated with water and electrolyte-containing fluids Supplement approaches Consider probiotics specifically formulated for diarrhoea Replenish electrolytes lost through diarrhoea with balanced supplements Try calcium supplements which may have mild constipating effects (consult healthcare provider first) Investigate digestive enzymes if food intolerances are suspected Use oral rehydration solutions for significant fluid losses Lifestyle adjustments Identify stress triggers that may worsen symptoms Practise stress reduction techniques such as meditation or deep breathing Maintain a food diary to identify specific food triggers Ensure easy access to toilets when outside the home Consider timing activities around predictable bowel patterns Medical interventions Over-the-counter antidiarrhoeal medications like loperamide (Imodium) for temporary relief Bismuth subsalicylate (Pepto-Bismol) for mild to moderate symptoms Oral rehydration salts (Dioralyte) to replace lost electrolytes and prevent dehydration Discuss with your clinician about adjusting your GLP-1 dosing schedule if diarrhoea is severe Ask about prescription medications for persistent diarrhoea that impacts quality of life Consider temporary dose reduction in consultation with your healthcare provider When to seek medical advice Contact your healthcare provider immediately if you experience: Diarrhoea lasting more than 2-3 days without improvement Signs of dehydration (excessive thirst, dark urine, dizziness) Blood or mucus in the stool Severe abdominal pain Fever above 38C (100.4F) Symptoms that significantly impact daily activities or quality of life Long-term outlook For most patients, diarrhoea is a temporary side effect that improves as the body adjusts to GLP-1 therapy
What insurance typically covers Coverage depends on why the medication is prescribed: Type 2 diabetes : Ozempic and Mounjaro are generally covered by commercial insurance and Medicare Part D when prescribed for diabetes management
