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Where the methyl group supply is limiting, GNMT activity is reduced in order to provide a greater supply for other SAM dependent methyltransferases

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Both hypomethylation and hypermethylation can lead to improper gene expression and are thus associated with certain health disorders, including development of cancer

High free-methionine and decreased lignin content result from a mutation in the Arabidopsis S-adenosyl-L-methionine synthetase 3 gene