Obesity drugs in clinical development Curr Opin Investig Drugs, 2006, AOD-9604 in the obesity drug pipeline PMID 26275694 Kwon DR, Park GY
Then theres the placebo effect
Response: We agree that the proposed rates based on a partial year of claims do not accurately reflect the costs for implementing, providing, and maintaining this service
however, cases of hypercobalaminemia in leukemia, autoimmune diseases, and pulmonary and renal dysfunction have also been observed (Andrs et al., 2013

MEPRIMET M4 FORTE TABLET - Glimepiride (4mg) + Metformin (1000mg) MEPRIMET MV1 TABLET - Glimepiride (1mg) + Metformin (500mg) + Voglibose (0.2mg) MEPRIMET MV2 TABLET - GLIMEPIRIDE 2MG+METFORMIN 500MG(SR)+VOGLIBOSE 0.2MG MEPRIMET P 1 TABLET - Glimepiride (1mg) + Metformin (500mg) (sr) + Pioglitazone (15mg) (double Color) MEPRIMET P 2 TABLET - Glimepiride (2mg) + Metformin (500mg) (sr) + Pioglitazone (15mg) (double MEPRIMET VG2 PLUS TABLET - Glimepiride (2mg) + Metformin (500mg) + Voglibose (0.3mg) MESADON 1200 TABLETS - MESALAMINE 1.2 GM LIPAZYME TABLET - Alpha Galactosidace(150mg), Lipase Enzyme(3mg), Protease Enzyme(50mcg), Lactase Enzyme(10mg) MESADON 400 TABLET - MESALAZINE DELAYED RELEASE 400MG TABLET MEPRIMET VG1 PLUS TABLET - Glimepiride (1mg) + Metformin (500mg) + Voglibose (0.3mg) LONESAFE 15 JUNIOR TABLET - Lansoprazole (15mg) LORATAN 50 TABLET - Losartan Potassium 50 mg LORATAN A 50 TABLET - Losartan Potassium 50 mg +AMLODIPINE 5MG TABLET LORATAN H 50 TABLET - Losartan Potassium 50 mg & Hydrochlorothiazide 12.5 mg METFIG L 2.5/1000 TABLET - LINAGLIPTIN(2.5MG) & METFORMIN(1000MG) TABLET METFIG L 2.5/500 TABLET - Linagliptin(2.5mg) & Metformin(500mg) Tablet METFIG L 5/1000 TABLETS - Each Film Coated Tablet Contains : Metformin Hydrochloride Ip 1000 Mg + Linagliptin 5 Mg + Excipients Q.s

It also depends on how the patient responds to the initial therapy