Some are prescribed for type 2 diabetes, some are prescribed for weight loss, and some are compared for both their metabolic and cardiovascular effects
In a 2018 analysis of clinical trial data, several researchers working with Novo Nordisk, the drugmaker for Ozempic and Wegovy, found that the drugs were safe and effective in adults over age 65, but noted that older adults reported discontinuation due to gastrointestinal issues at a higher rate than younger participants did
In particular, vagal afferent neurons expressing the GLP-1R are necessary for GLP-1 mediated induction of satiety (167) but not glucose lowering effects (168)
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It is explicitly not framed as the right answer for everyone
Although this study involved a small patient sample, I have had similar experiences in my practice, said Mir Ali, MD, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, who wasnt involved in the study
