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Activated neutrophils release ROS, proteases (e.g., neutrophil elastase), and neutrophil extracellular traps (NETs), contributing to tissue damage and mucus hypersecretion (105)

This creates a beneficial cycle: better gut function supports better brain function, which in turn may improve gut-brain signaling

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QM/MM calculations Enzymesubstrate complexes were generated through molecular docking using the GOLD software 76 (ChemScore fitness function) on the crystal structure of PtGSTF8 preserving crystallographic Na + ions and flav-3-on-4-ol coordinates optimized at the B3LYP/6-31 G(d) quantum mechanical level (see below for details)

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Chronic oral inflammation correlates with insulin resistance and neurodegeneration