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Recently, Bharaj et al

The mechanisms of elevations of IL-17A that lead to ASD may involve alterations of the function of regulatory T (Treg) cells

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And around one in three early responders in later analyses went on to lose more than 20% of their starting weight by the end of the study

This can be an important consideration as one could argue that patients taking GLP-1RAs might differ, compared with patients not on these medications, in their likelihood to have seen an eye care clinician. The commentary encouraged others to take a critical look at the designs and database limitations to understand how confounding, bias and chance may explain discrepancies in studies that rely on large databases

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