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In sex-specific analysis, as for l-carnitine, genetically predicted acetyl-carnitine was also related to higher risk of CAD in men (OR 1.09, 95% CI 1.02 to 1.16) but not in women (OR 1.00, 95% CI 0.92 to 1.09) (Additional file 2: Fig

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These receptors are activated when peptide ligands interact with extracellular receptor domains, producing conformational changes that initiate intracellular signaling