Mechanism of action of Tirzepatide (source: Lilly website) Different doses of Mounjaro were evaluated in five clinical trials as a stand-alone therapy or in combination with other diabetes medications
It's often the case that insurance coverage is restricted to confirmed diabetes treatments
Weddell J, Rogerson MC, Gallagher R, Hesselson S, Iismaa SE, Graham RM, et al
Mounjaro's dual-action mechanism (targeting both GIP and GLP-1 receptors) has shown greater average weight loss in clinical trials: 20-22% with Mounjaro compared to approximately 15% with Wegovy
specifically, (AEEA)-(-Glu)-(C20 diacid) (where AEEA is 2-[2-(2-aminoethoxy)ethoxy]acetic acid, commonly used as a spacer group in synthetic peptides)
Statements Author contributions J-YW and Q-WW wrote the first draft of the manuscript