Information provided is for educational purposes only and has not been evaluated by the FDA
[4] In patients with cyanide poisoning, hydroxocobalamin also acts as an antidote by binding to cyanide ions with high affinity to form nontoxic cyanocobalamin
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
This applies to licensed and unlicensed products alike and helps the MHRA monitor the safety of medicines used in the UK
Due to its interaction with NNMT-associated pathways, 5-Amino-1MQ has become a significant area of interest in laboratory research involving metabolism, cellular energy expenditure, adipocyte biology, and nutrient utilization mechanisms
Treatment with methylcobalamin or hydroxocobalamin may unmask this condition
