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This article explains how each agent works, what the current evidence shows, the safety considerations patients should understand, and how to access emerging obesity treatments safely through regulated NHS and clinical trial pathways

Unrepaired 8-oxo-G is potentially one of the most mutagenic lesions, since it pairs with A, inducing G T transversions 40 , and represents a prominent candidate to be a marker of ROS-induced mutagenesis and tumorigenesis 41

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Redox Biology 11, 297311