The SP@M treatment led to a significant decrease in the fluorescence intensity of CD86 (the phenotypic marker of M1-like macrophages) and an increase in the intensity of CD206 (the phenotypic marker of M2-like macrophages), indicating the remission of pro-inflammatory microenvironment (Supplementary Fig
10.1002/oby.21033 Obesity 95 NavarroG.XuW.JacobsonD
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Although there are no direct models of DLB, evidence can be extrapolated from PD models and clinical studies, which (as above) demonstrate GLP-1RAs exert broad neuroprotective actions: attenuating pathological protein aggregation, improving impaired insulin signaling, and reducing neuroinflammation
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En todas las revisiones, hubo poca o ninguna diferencia entre estos medicamentos y el placebo en cuanto a los episodios cardiovasculares graves, la calidad de vida o la mortalidad
