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**Gallbladder Disease**: Some studies have found an increased risk of gallbladder problems, including gallstones, in patients taking GLP-1 agonists and dual agonists

doi: 10.2146/ajhp150990 5 HirschIB

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That is encouraging because it suggests stronger fat loss does not necessarily come with disproportionately worse lean-mass loss

visceral fat fell about 40%. After withdrawal, insulin resistance returned in proportion to regained weight. Maintaining some weight loss did not preserve the full metabolic benefit when substantial regain occurred