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In summary, the reported inactive GLP-1R crystal structure reveals a unique closed conformation of the ECD, and a deeper understanding of the conformational dynamics of GLP-1R was elaborated by EM and MD simulations

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doi:10.2164/jandrol.106.000646

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10.17235/reed.2020.7444/2020 180 SahooG.SamalD.KhandayatarayP.MurthyM

it is a measurable, biochemical failure at the cellular level