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Key Differences: Mechanism, Duration, and Side Effects Phentermine operates as a central nervous system stimulant that suppresses appetite through norepinephrine release, while GLP-1 agonists work through peptide hormone pathways that regulate multiple body systems simultaneously

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It is one of the twelve peptides the FDA removed from the list that restricted compounding in April 2026, and one of seven under formal advisory review on July 2324, 2026

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