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Peer review Peer review information Nature Communications thanks Hongli Mao, and the other, anonymous, reviewer for their contribution to the peer review of this work

When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

Aftercare Apply CU Restore repair cream daily following treatment

A psychiatric disorder is formed due to the complex interplay of environmental factors and genetic vulnerability (Souza et al., 2023)

7 Previously, DAO deficiency was reported in 80% of 31 adult patients experiencing various HIT symptoms, some of which included urticaria, pruritus, abdominal pain, diarrhea, constipation, vomiting, headache, rhinitis, and cough

Kisses, Paola