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Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

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Quick Answer: Original Russian protocol: 5 to 10 mg SC daily for 10 to 20 days, 2 to 4 cycles per year Total annual exposure under these protocols ranges from roughly 100 mg (5 mg x 10 days x 2 courses) to 800 mg (10 mg x 20 days x 4 courses)

Subsequent to this initially characterized GHS, numerous peptide and non-peptide compounds were developed and shown to exert related GHS activity