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Reporting only the maximum result can create an exaggerated impression that the treatment extended life generally

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To address this question, we performed an integrated time-resolved analysis of the renal transcriptome and proteome in parallel with the renal and plasma metabolomes in control mice and mice with an induced deletion of Bmal1 in the renal tubule

These findings imply that NRF2 is of great importance for maintaining iron/heme homeostasis [99, 104]