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In clinical research, dose escalation and monitoring rules are set by a study protocol

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New Phytol 224:15691584 Maynard D, Kumar V, Spro J, Dietz K-J (2020) 12-Oxophytodienoic acid reductase 3 (OPR3) functions as NADPH-dependent , -ketoalkene reductase in detoxification and monodehydroascorbate reductase in redox homeostasis