In this trial, amifostine may have protected against long-term kidney insufficiency from cumulative doses of cisplatin, and the combination treatment appeared highly active against the cancer (Schiller 1996)
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It is postulated that DM-induced oxidative damage may be more significant in erythrocytes than in other cells, due to their high content of iron and polyunsaturated fatty acids, as well as their role as oxygen transporters, with a high degree of exposure to free radicals [320]
Coupled steady-state kinetic measurements with GSSR and GSH revealed that both half-reactions usually occur with second order rate constants around 10 5 to 10 6 M 1 s 1 with the reductive half-reaction being slower for wild-type glutaredoxins 11,14,15,17,19
purity of 98%