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For power calculation, SD between 45 and 55 kcal/day and effect sizes between 36 and 84 kcal/day were used based on in-silico trial simulations using existing validated models (24,29,30) using SAR425899 phase 1 trial data as input (13)

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Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance