According to epidemiological surveys, CCVDs are very common among middle-aged people over 50, and have become the top one killer of people (Singh et al., 2015), accounting for almost one-third of global deaths every year (2015)
The key role of GSH as an antioxidant is demonstrated by many studies showing that experimental depletion of GSH levels which can be achieved with various chemicals the most used of which is buthionine sulfoximine (BSO) an inhibitor of GSH synthesis has a worsening effect in many disease models
Elucidation of its pharmacological mechanism through molecular docking suggested luteolin as one of three main active components closely related to asthma, specifically the IL-17 inflammatory pathway [158]
GSH exists in two main forms: reduced monomers (GSH) and oxidized dimers, glutathione disulfide (GSSG)
This risk was more pronounced in those under 65 years of age
It is more stable, longer-lasting and clinically superior to cyanocobalamin a cheaper synthetic form widely used in beauty salons and non-medical clinics that contains a small amount of cyanide which the body must detoxify
