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In the phase 2 trial, the largest average rise was about 6.7 beats per minute at 24 weeks on the highest 12 mg dose, with rates declining again by weeks 36 to 48

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In contrast, later in 2023, a multisociety statement from gastroenterology and hepatology organizations, including the AGA, AASLD, ACG, ASGE, and NASPGHAN, advised against routine discontinuation of GLP-1 therapy, emphasizing individualized patient management and the use of point-of-care gastric ultrasound (POCUS) to assess aspiration risk [9]

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