Human germline mutations in glutarate metabolism highlight its fundamental biological role, with loss of function mutations in glutaryl-CoA dehydrogenase (GCDH) resulting in glutarate accumulation and glutaric aciduria type 1 (GA1)a rare autosomal disorder characterized by dystonia, developmental delay and often death in early childhood 10
PMID: 41763214 bioRxiv2024 August 11
Remember, more is not always better, and targeted supplementation based on identified needs is the most evidence-based approach
Schedule: Subcutaneous injections 5 days per week (or 3/week) for 812 weeks, optionally extended to ~16 weeks
Cardiovasc Drugs Ther (2015) 29(3):24355
Additionally, side effects like nausea and vomiting can contribute to dehydration, making it crucial to maintain adequate fluid intake