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Meningeal macrophages die following compression injury (see Video 1), and microglia immediately retract their ramified processes and extend them toward the glial limitans, forming a vast network resembling a honeycomb

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Proceed with extra caution or consider topical-only formulations

A 2025 study published in Frontiers in Pharmacology examined GHK-Cu's effects in a colitis model, finding that it modulated SIRT1 and STAT3 signaling in colon tissue a reminder that this peptide's research footprint extends well past skin and hair into broader inflammatory and metabolic pathways