A 4 mg maintenance dose, stepped down after the primary weight-loss phase, is aimed at the real-world question of how to hold a 25-28% loss over years without keeping participants on a dose level that many cannot tolerate indefinitely
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Weight loss alone significantly reduces the burden on the heart, lowering blood pressure, reducing harmful LDL cholesterol, and improving triglyceride levels
During this phase, administer tesamorelin at 1mg daily (half the standard dose) to assess tolerance
Thats enough to help regulate appetite, cravings, and energy in many perimenopausal and menopausal women, without pushing the body into the more aggressive metabolic shifts that can sometimes lead to nausea, fatigue, or rapid muscle loss
Routine follow-up visits create opportunities to reassess weight, HbA1c, blood pressure, medication tolerance, and lifestyle habits