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Gastrointestinal symptoms were reported early after the initiation of treatment but resolved spontaneously

Extended evaluations of degradation kinetics, immunogenicity, and mechanical stability are required to confirm long-term safety and efficacy

Counter-measures include adequate water intake (minimum 64 ounces daily), fiber supplementation during eating windows, and magnesium citrate before bed if needed

10.1016/j.nbd.2008.03.008 13 HeadS

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Noseda R, Hernndez A, Valladares L et al (2004) Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT2 receptor-dependent