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Tirzepatide produced approximately 20.2% weight loss versus 13.7% for semaglutide about 47% more weight loss on an absolute basis

Chirulli, V

It said it did "not consider it appropriateto debate or promote the evidence base for particular compounds" and relied on the "clinical judgement of the practitioner", claiming they operate within the rules

Its worth being clear-eyed about the studys limits: it was a single-center, retrospective chart review, not a randomized trial, and nearly a third of patients discontinued the medication, most often due to gastrointestinal side effects

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