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Diabetologia 40 , 205211 (1997)

As with any medication that affects metabolism, ongoing medical supervision is essential to watch for less common but more serious effects

Tirzepatide use increased over time, consistent with broader population trends (15)

A recent study found that more than 50% of people who stopped taking their GLP-1 were able to keep their weight off or continue losing weight after one year

Polymeric nanoparticles, especially those derived from PLGA (poly(lactic-co-glycolic acid)), have been used to prepare long-acting formulations of GLP-1 that can extend the release period to weeks with a single dose, reducing injection frequency and improving patient adherence [33]

Metabolism GLP-1 gets rapidly metabolized in the circulation by dipeptidyl peptidase-4 (DPP-IV), resulting in a short plasma half-life of approximately 2 min [11]