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[PubMed: 21402690] 44

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Animal studies support this, with effective doses in rats being considerably higher on a weight basis than typical human doses, raising the possibility that some clinical trials may have used subtherapeutic dosing

Are there any underlying conditions contributing to my B12 deficiency

G-protein-coupled receptors constitute the largest family of membrane proteins, and ligand binding can lead to activation of multiple intracellular pathways, including G proteins, beta-arrestins, and other non-G-protein-regulated signaling pathways, such as mitogen-activated protein kinase phosphorylation [20] (Figure 3)

Note that the cycle for tissue regeneration, healing, and repair is conditional: its a therapeutic goal with a defined end point, so you can discontinue use once youve reached it